DENVER — Rarely has playing it safe paid off so well for the Pittsburgh Steelers.

Tyrone Carter started in place of safety Ryan Clark as a precaution Monday night and made the big play that sparked the Steelers to their fifth straight win, taking the first of his two interceptions 48 yards for a touchdown in Pittsburgh’s 28-10 win over the Denver Broncos.

Clark nearly died following a game in Denver two years ago because of a rare blood disorder that is aggravated by playing in high altitude, so Steelers coach Mike Tomlin decided to hold him out of the game.

He said he didn’t want to risk Clark’s health or burden his teammates and family members with worry.

Carter capped his night with his second interception with

15 seconds left, and Clark, dressed in charcoal sweats and a smile on the sideline, jumped up and down in celebration.

Hines Ward caught two short touchdown passes from Ben Roethlisberger, including one in which he hauled in a pass in the flat and hurdled cornerback Champ Bailey on his way into the end zone, a final indignity for Denver that capped the scoring with 1:22 remaining and emptied the stadium.

Rashard Mendenhall rumbled over the Broncos for

155 yards on 22 carries as the Steelers (6-2) handed Denver its second straight loss after the Broncos opened the season

6-0 under rookie coach Josh McDaniels.

Carter’s first interception return gave Pittsburgh a

7-3 halftime lead even though the Steelers had generated just three first downs and were outgained 183-54 in the first half.

An ecstatic Clark was among the first players to swarm Carter, the first defender to pick off a Kyle Orton pass all season.

His only interception before throwing three Monday night was a Hail Mary that Patriots wide receiver Randy Moss pulled down in a game last month.

As he left the field, Clark clicked his heels and jokingly hollered, “I’m going home, and I’m not playing the rest of the year.”

With the Steelers clinging to a 14-10 lead in the fourth quarter, safety Troy Polamalu snared another Orton pass, this one at the Broncos 25-yard line, leading to Roethlisberger’s 25-yard TD toss to rookie Mike Wallace.

Denver scored on its opening drive for the first time this season. But the Broncos had to settle for Matt Prater’s 40-yard field goal after cornerback William Gay broke up a pass at the 10 to Eddie Royal, who had three receptions for 47 yards on the 56-yard drive.

The Broncos stopped themselves over and over again on offense, with Orton making poor passes and bad decisions and his receivers making uncharacteristic mistakes.

Carter, who was Polamalu’s fill-in for a month when Polamalu had an injured knee earlier this season, had an easy pickoff when rookie running back Knowshon Moreno, Orton’s target, ran into an official as Orton was releasing the short pass over the middle, and Carter raced into the end zone untouched for a 7-3 lead.

The Broncos’ defense retaliated on the opening drive of the second half when Kenny Peterson swooped in and punched the ball out of Roethlisberger’s hands. Rookie linebacker Robert Ayers scooped it up and rumbled 54 yards for a touchdown that gave Denver a 10-7 lead.

It didn’t last long.

Roethlisberger, who was

21-for-29 for 233 yards, drove the Steelers 80 yards in four plays, hitting Ward with a 3-yard strike over the outstretched right arm of linebacker D.J. Williams to put Pittsburgh ahead for good, 14-10.

Roethlisberger drove the Steelers to the Denver 15 on the Steelers’ next possession, but he threw behind Ward in the end zone and cornerback Andre’ Goodman picked it off – Big Ben’s first red-zone interception since 2007.

The Steelers dominated the second half by going no-huddle with three-wide receiver sets, which kept Elvis Dumervil, who has 10 1/2 sacks, on the sideline much of the time.

Clark was one of three Steelers defensive starters sitting out, joining defensive end Travis Kirschke (calf) and linebacker Lawrence Timmons (ankle). It hardly mattered as Denver managed just 59 yards on six second-half drives.

By the closing minutes, Invesco Field was a sea of yellow Terrible Towels and thousands of empty blue seats, orange giveaway pom-pons littering the aisles.

NOTES: Orton was 7 for 17 for 58 yards after halftime after going 16 for 21 for 163 yards in the first half. ... 35-year-old CB Ty Law made his debut for Denver two days after signing with the Broncos. He was signed to cover slot receivers after Baltimore quarterback Joe Flacco had a field day against the Broncos’ secondary last week. ... The Broncos were without starting right tackle Ryan Harris (toe) and defensive lineman Ryan McBean (knee). ... Halftime ceremonies included a Veteran’s Day salute to America’s armed forces.